ConKerr Cancer started when Cindy Kerr's son Ryan was diagnosed with cancer in 2002. She began making pillowcases to brighten up his hospital room and to put a smile on his face. He loved it and so she began making pillowcases for other children on the Oncology Unit at Children's Hospital Philadelphia. The goal of ConKerr Cancer is to make hospital stays as pleasant as possible for chronically ill children and their parents. Since its creation, "A Case for Smiles", has provided over 240,000 pillowcases made by thousands of volunteers from across North America and South Africa and keeps growing.
In 2010, it expanded to Europe with the creation of the first European chapter at Oxford, United Kingdom. Sylvia Rueda is the coordinator of ConKerr Cancer Oxford. She works with wonderful volunteers that make pillowcases for the children at the Kamran's ward (Haematology and oncology), Children's hospital, John Radcliffe Hospital, Oxford.